Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione Complex Detox Support Supplement Quicksilver L Glutathione 500mg LAC Codeage Liposomal Glutathione Review Does It Actually Work? What is glutathione and why must we protect patient access to it? Glutathione Depleting Pro Oxidant as a Selective Anticancer Therapeutic Agent ACS Omega