What is a MTHFR gene mutation? Methyl Life Supplements Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Converging Evolutionary, Environmental and Clinical Ideas on Folate Metabolism What is the MTHFR Gene Mutation and Its Role in Health? Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer BMC Cancer Springer Nature Link The detox gene (MTHFR) is rendered inactive when your diet is high in meat. Our diet should be 80% plant based or higher.